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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
22.42
Human Site:
S405
Identified Species:
32.89
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
S405
E
V
K
Y
E
P
F
S
F
A
D
D
I
G
S
Chimpanzee
Pan troglodytes
P60051
493
55922
S405
E
V
K
Y
E
P
F
S
F
A
D
D
I
G
S
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
D373
Y
E
P
F
S
F
A
D
D
I
G
S
N
N
C
Dog
Lupus familis
XP_537306
545
61461
S456
E
V
K
Y
E
P
F
S
F
A
D
D
I
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
S404
E
I
K
Y
E
P
F
S
F
A
D
D
I
G
S
Rat
Rattus norvegicus
NP_001008302
493
55958
S404
E
I
K
Y
E
P
F
S
F
A
D
D
I
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
D346
E
P
F
S
F
P
D
D
I
G
S
N
N
C
G
Chicken
Gallus gallus
XP_419150
492
55612
S403
E
V
K
Y
E
P
F
S
F
P
D
D
I
G
S
Frog
Xenopus laevis
Q6GNI6
523
60030
V402
T
M
K
K
L
P
I
V
A
C
F
H
L
K
R
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
D414
V
S
F
P
L
E
L
D
M
T
P
F
M
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
E389
E
K
K
D
V
K
Y
E
Q
F
W
F
D
D
D
Honey Bee
Apis mellifera
XP_395043
497
56311
W402
K
V
K
Q
E
S
F
W
F
P
D
D
I
G
S
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
A379
D
G
V
A
L
P
T
A
F
E
D
D
A
G
S
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
D416
D
V
K
Y
L
P
Y
D
F
P
D
D
I
G
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
A384
V
K
M
T
D
A
E
A
S
A
N
G
S
G
E
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
L400
Q
Y
E
T
Q
V
A
L
N
E
S
E
K
D
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
0
100
N.A.
93.3
93.3
N.A.
13.3
93.3
13.3
6.6
N.A.
13.3
66.6
40
60
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
20
93.3
26.6
13.3
N.A.
20
73.3
53.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
7
13
13
7
38
0
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
13
% C
% Asp:
13
0
0
7
7
0
7
25
7
0
57
57
7
13
7
% D
% Glu:
50
7
7
0
44
7
7
7
0
13
0
7
0
0
7
% E
% Phe:
0
0
13
7
7
7
44
0
57
7
7
13
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
7
7
7
0
63
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
13
0
0
0
0
7
0
7
7
0
0
50
0
0
% I
% Lys:
7
13
63
7
0
7
0
0
0
0
0
0
7
7
0
% K
% Leu:
0
0
0
0
25
0
7
7
0
0
0
0
7
0
0
% L
% Met:
0
7
7
0
0
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
0
7
7
13
7
0
% N
% Pro:
0
7
7
7
0
63
0
0
0
19
7
0
0
0
0
% P
% Gln:
7
0
0
7
7
0
0
0
7
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
7
0
7
7
7
0
38
7
0
13
7
7
0
57
% S
% Thr:
7
0
0
13
0
0
7
0
0
7
0
0
0
0
0
% T
% Val:
13
38
7
0
7
7
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% W
% Tyr:
7
7
0
44
0
0
13
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _